Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease

Abstract Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anc...

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Detalhes bibliográficos

Principais autores:	Arnaud Chignon, Samuel Mathieu, Anne Rufiange, Déborah Argaud, Pierre Voisine, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault, Patrick Mathieu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
Colecção:	Human Genomics
Assuntos:	Atherosclerosis Coronary artery disease Genes 3D genome Mendelian randomization Druggable genome
Acesso em linha:	https://doi.org/10.1186/s40246-022-00381-4
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