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Macrophages protect against loss of adipose tissue during cancer cachexia

Abstract Background Cancer cachexia represents a central obstacle in medical oncology as it is associated with poor therapy response and reduced overall survival. Systemic inflammation is considered to be a key driver of cancer cachexia; however, clinical studies with anti‐inflammatory drugs failed...

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Principais autores: Merve Erdem, Diana Möckel, Sandra Jumpertz, Cathleen John, Athanassios Fragoulis, Ines Rudolph, Johanna Wulfmeier, Jochen Springer, Henrike Horn, Marco Koch, Georg Lurje, Twan Lammers, Steven Olde Damink, Gregory van derKroft, Felix Gremse, Thorsten Cramer
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2019-10-01
coleção:Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
Cancer‐associated cachexia
Hepatocellular carcinoma
Visceral adipose tissue
Macrophages
HIF‐1α
Acesso em linha:https://doi.org/10.1002/jcsm.12450
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