Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution, yet direct quantification of double-strand breaks (DSBs) has been limited. Predominant sources of spontaneous DSBs remain elusive. We report synthetic technology for quantifying DSBs using fluorescent-protein fusions of...

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Autores principales:	Chandan Shee, Ben D Cox, Franklin Gu, Elizabeth M Luengas, Mohan C Joshi, Li-Ya Chiu, David Magnan, Jennifer A Halliday, Ryan L Frisch, Janet L Gibson, Ralf Bernd Nehring, Huong G Do, Marcos Hernandez, Lei Li, Christophe Herman, PJ Hastings, David Bates, Reuben S Harris, Kyle M Miller, Susan M Rosenberg
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2013-10-01
Colección:	eLife
Materias:	DNA double-strand break endogenous DNA damage GFP fluorescent-protein fusion spontaneous DNA break synthetic biology
Acceso en línea:	https://elifesciences.org/articles/01222
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