Expression, Purification and Characterization of a Novel Hybrid Peptide CLP with Excellent Antibacterial Activity

CLP is a novel hybrid peptide derived from CM4, LL37 and TP5, with significantly reduced hemolytic activity and increased antibacterial activity than parental antimicrobial peptides. To avoid host toxicity and obtain high-level bio-production of CLP, we established a His-tagged SUMO fusion expressio...

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Hauptverfasser:	Junhao Cheng, Marhaba Ahmat, Henan Guo, Xubiao Wei, Lulu Zhang, Qiang Cheng, Jing Zhang, Junyong Wang, Dayong Si, Yueping Zhang, Rijun Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-11-01
Schriftenreihe:	Molecules
Schlagworte:	hybrid peptide antimicrobial peptide <i>Escherichia coli</i> fusion expression antibacterial activity
Online-Zugang:	https://www.mdpi.com/1420-3049/26/23/7142
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