Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo
Abstract Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for methylation. Achieving three chemically dist...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
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Nature Portfolio
2023-10-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/s41467-023-42037-4 |
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