Complement C3 inhibition restores myasthenia gravis AChR antibody-mediated muscle pathophysiologyResearch in context

Summary: Background: In the autoimmune disorder myasthenia gravis (MG), the nicotinic acetylcholine receptors (nAChRs) are the primary targets of pathogenic antibodies. While MG mechanisms have been extensively studied in animal models, functional insights into how antibody binding disrupts nAChR-d...

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Hauptverfasser:	Yu-Fang Huang, Amol Keshavasa Bhandage, Miriam L. Fichtner, Anna Rostedt Punga
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-07-01
Schriftenreihe:	EBioMedicine
Schlagworte:	Myasthenia gravis Nicotinic acetylcholine receptors VGCCs Calcium signaling C3 Complement inhibition
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352396426002045
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