Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

Summary: Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc alone induce a metabolic-inflammatory transcripti...

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Bibliographic Details

Main Authors:	Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2022-03-01
Series:	Cell Reports
Subjects:	MSU crystals transcriptional regulation JNK AP-1 activation macrophage gout
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124722002224
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