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OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts

SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors. We now show that, like OCT4, SOX2 functions as a transcriptional activator. We...

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Principais autores: Santosh Narayan, Gene Bryant, Shivangi Shah, Georgina Berrozpe, Mark Ptashne
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2017-08-01
סדרה:Cell Reports
נושאים:
reprogramming
iPSCs
enhancers
transcription
transcription factors
stem cells
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2211124717310641
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