Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

A fundamental part of the immune response to infection or injury is leukocyte migration. Matrix metalloproteinases (MMPs) are a class of secreted or cell-bound endopeptidases, implicated in every step of the process of inflammatory cell migration. Hence, specific inhibition of MMPs is an interesting...

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Autores principales:	Elisa Nuti, Armando Rossello, Doretta Cuffaro, Caterina Camodeca, Jens Van Bael, Dries van der Maat, Erik Martens, Pierre Fiten, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Mieke Gouwy, Ghislain Opdenakker, Jennifer Vandooren
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2020-07-01
Colección:	Cells
Materias:	MMP-9 inflammation endotoxemia leukocytosis chemotaxis sepsis
Acceso en línea:	https://www.mdpi.com/2073-4409/9/7/1634
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