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Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

Abstract Microglia nodules (HLA-DR+ cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first stage of multiple sclerosis (MS) lesion formation. We show that microglia nodules are associated with more severe MS pathology. Compared...

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Váldodahkkit: Aletta M. R. van den Bosch, Marlijn van der Poel, Nina L. Fransen, Maria C. J. Vincenten, Anneleen M. Bobeldijk, Aldo Jongejan, Hendrik J. Engelenburg, Perry D. Moerland, Joost Smolders, Inge Huitinga, Jörg Hamann
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2024-02-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-024-46068-3
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