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Characterization of full-length and cytoplasmic tail-truncated envelope glycoproteins incorporated into human immunodeficiency virus (HIV-1) virions and virus-like particles

ABSTRACT During transport to the surface of infected cells, the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer is cleaved to produce the mature functional Env trimer [(gp120/gp41)3]. Env cleavage stabilizes the pretriggered Env conformation (PTC), the major target for broadl...

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Principais autores: Saumya Anang, Shijian Zhang, Amanda Ennis, Haitao Ding, Ashlesha Deshpande, Hanh T. Nguyen, John C. Kappes, Joseph G. Sodroski
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2025-12-01
coleção:Journal of Virology
Assuntos:
furin
protease
cleavage
ESCRT
extracellular vesicles
virus-like particles
Acesso em linha:https://journals.asm.org/doi/10.1128/jvi.01585-25
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