A mitochondrial regulatory network of ferroptosis defense in HPV-positive cervical cancer: therapeutic implications of the mitoSTAT3-DHODH axis

Human papillomavirus (HPV)-positive cervical cancer develops under persistent metabolic, replicative, and oxidative stress and frequently exhibits limited sensitivity or acquired resistance to cisplatin-based concurrent chemoradiotherapy (CCRT). In this context, ferroptosis represents a potential th...

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Principais autores:	Shi Feng, Yang Huang, Zhi Li, Zhanxu He, Yuhong Gao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
Colecção:	Frontiers in Pharmacology
Assuntos:	ferroptosis HPV-positive cervical cancer lipid peroxidation mitoSTAT3-DHODH axis oxidative stress
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1868059/full
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