Targeting Plasmodium falciparum with purine antimetabolites as a therapeutic strategy
Plasmodium falciparum lacks the de novo purine biosynthesis pathway and relies exclusively on salvaging free purines from the host to meet its metabolic requirements. This absolute dependence on the purine salvage pathway provides a compelling opportunity for antimalarial drug development, particula...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2026-03-01
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| Colección: | Frontiers in Microbiology |
| Materias: | |
| Acceso en línea: | https://www.frontiersin.org/articles/10.3389/fmicb.2026.1773050/full |
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