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Integrative network toxicology and multi-omics analysis reveals potential mechanisms of imidacloprid-induced neurotoxicity in SH-SY5Y cells and Caenorhabditis elegans

Imidacloprid (IMI), a widely used neonicotinoid insecticide, has been associated with neurotoxic effects; however, the system-level mechanisms underlying these effects remain incompletely understood. Here, we integrated network toxicology with multi-omics analyses to investigate IMI-induced neurotox...

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Principais autores: Xingang Hou, Kai Wang, Zhiguang Hou, Liping Wei, Zheng Zhang, Xiaojiao Zheng, Yuzhen Wang, Meng Lv, Jiangxin Tian, Zhaoyang Wang, Chao Ma, Fanrong Zhao, Jiajun Han
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-06-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
Imidacloprid
Neurotoxicity
SH-SY5Y
Caenorhabditis elegans
Multi-omics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651326005154
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