Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of <i>rac</i>-5β-Hydroxy-<span style="font-variant: small-caps">d</span>-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

An efficient synthesis of <i>rac</i>-6-desmethyl-5β–hydroxy-<span style="font-variant: small-caps;">d</span>-secoartemisinin <b>2</b>, a tricyclic analog of <i>R</i>-(+)-artemisinin <b>1</b>, was accomplished and the racemate was resolved into the (+)-<b>2b</b> and (−)-<b>2a</b> enantiomers via thei...

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Principais autores:	Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely, John Rimoldi, Shabana I. Khan, Mitchell A. Avery
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2021-07-01
叢編:	Molecules
主題:	artemisinin racemate enantiomers Mosher ester diastereomers <i>Plasmodium falciparum</i>
在線閱讀:	https://www.mdpi.com/1420-3049/26/14/4163
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