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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis [version 1; peer review: 2 approved, 1 approved with reservations]

Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Corticosteroids are currently recommended as an adjunctive therapy in HIV-negative adults with TBM. However, benefit from corticosteroids in TBM may depend upon host leukotriene A4 hydrolase (LTA4H) genotype and the corresponding...

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Principais autores: Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat
Format: Artigo
Sprog:Inglês
Udgivet: Wellcome 2024-11-01
Serier:Wellcome Open Research
Fag:
tuberculous meningitis
corticosteroids
clinical trial
analysis plan
leukotriene A4 hydrolase (LTA4H)
personalised medicine
eng
Online adgang:https://wellcomeopenresearch.org/articles/9-695/v1
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