Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis

Summary: Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying that hazard and whether it arises from direct inhibition of cardiomyocyte α1-ARs or from systemic effects remain unclear. To address th...

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Principais autores:	Jiandong Zhang, MD, PhD, Peyton B. Sandroni, BS, Wei Huang, MS, Xiaohua Gao, PhD, Leah Oswalt, PhD, Melissa A. Schroder, BS, SungHo Lee, DVM, PhD, Yen-Yu I. Shih, PhD, Hsiao-Ying S. Huang, PhD, Philip M. Swigart, MS, Bat E. Myagmar, MD, PhD, Paul C. Simpson, MD, Joseph S. Rossi, MD, Jonathan C. Schisler, PhD, Brian C. Jensen, MD
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-01-01
Series:	JACC: Basic to Translational Science
Assuntos:	adrenergic α1 receptor antagonists myocardial infarction necroptosis receptors adrenergic alpha
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2452302X23004187
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