Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation

ABSTRACT The yeast-to-hypha transition is a key virulence attribute of the opportunistic human fungal pathogen Candida albicans, since it is closely tied to infection-associated processes such as tissue invasion and escape from phagocytes. While the nature of hypha-associated gene expression require...

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Detalhes bibliográficos

Principais autores:	Enrico Garbe, Franziska Gerwien, Dominik Driesch, Tina Müller, Bettina Böttcher, Markus Gräler, Slavena Vylkova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-12-01
coleção:	mSystems
Assuntos:	Candida albicans filamentation metabolomics metabolic adaptation sphingolipids hyphal development
Acesso em linha:	https://journals.asm.org/doi/10.1128/msystems.00539-22
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