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DNA Sequence Changes Resulting from Codon Optimization Affect Gene Expression in <i>Pichia pastoris</i> by Altering Chromatin Accessibility

Codon optimization is a widely employed strategy to enhance protein expression. However, it occasionally leads to unexpected transcriptional repression despite preserving amino acid sequences. This study investigates the mechanistic basis of such transcriptional attenuation by analyzing two gene can...

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Principais autores: Chaoyu Lu, Linna Guo, Bohao Fang, Jiacheng Shi, Mian Zhou
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-04-01
Serier:Journal of Fungi
Fag:
codon usage bias
nucleosome occupancy
chromatin accessibility
<i>Pichia pastoris</i>
Online adgang:https://www.mdpi.com/2309-608X/11/4/282
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