Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models

Abstract Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal transduction mechanism that is activ...

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Principais autores:	Allyssa Bradley, Soyoung Park, Soyeon Park, Kyle Kim, Angela Galdamez, Hyejung Min, Monica Sophia Diaz-Aguilar, M. Elizabeth Hartnett, Eun-Jin Lee, Jonathan H. Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-09-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-025-15393-y
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