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The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several experimental models for the disease. We show here that...

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Principais autores: Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-03-01
coleção:Molecules
Assuntos:
pancreatic cancer
quadruplex
biophysics
S100P
transcriptome
MIA PaCa-2 xenograft
Acesso em linha:https://www.mdpi.com/1420-3049/28/6/2452
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