Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells

Methionine (Met) is an essential amino acid and critical precursor to the cellular methyl donor S-adenosylmethionine. Unlike nontransformed cells, cancer cells have a unique metabolic requirement for Met and are unable to proliferate in growth media where Met is replaced with its metabolic precursor...

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Autors principals:	Stacey L. Borrego, Johannes Fahrmann, Jue Hou, Da-Wei Lin, Bruce J. Tromberg, Oliver Fiehn, Peter Kaiser
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-01-01
Col·lecció:	Journal of Lipid Research
Matèries:	cancer metabolism homocysteine methionine methionine stress lipid metabolism lipid droplets
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0022227521000389
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