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Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.

Serotonin is a ubiquitous chemical transmitter with particularly important roles in the gastrointestinal, cardiovascular and central nervous systems. Modulation of serotonergic signaling occurs, in part, by uptake of the transmitter by the serotonin transporter (SERT). In the brain, SERT is the targ...

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Auteurs principaux: Evan M Green, Jonathan A Coleman, Eric Gouaux
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2015-01-01
Collection:PLoS ONE
Accès en ligne:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145688&type=printable
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