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Flipping the Target: Evaluating Natural LDHA Inhibitors for Selective LDHB Modulation

Lactate dehydrogenase (LDH) catalyzes the reversible interconversion of pyruvate and lactate, coupled with the redox cycling of NADH and NAD<sup>+</sup>. While LDHA has been extensively studied as a therapeutic target, particularly in cancer, due to its role in the Warburg effect, LDHB remains under...

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Principais autores: Amanda El Khoury, Christos Papaneophytou
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-07-01
coleção:Molecules
Assuntos:
lactate dehydrogenase B
natural products
cancer metabolism
allosteric inhibition
isoform selectivity
Acesso em linha:https://www.mdpi.com/1420-3049/30/14/2923
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