Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations

Abstract Background Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation data of NSCLC patients with EGFR-sensitive mutations and high programm...

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Hlavní autoři:	Wuwu Ding, Pengmin Yang, Xiaokai Zhao, Xiaozhi Wang, Huaqing Liu, Qing Su, Xintao Wang, Jieyi Li, Ziying Gong, Daoyun Zhang, Xinwei Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-01-01
Edice:	Respiratory Research
Témata:	EGFR-TKIs PD-L1 TMB Resistance PI3K signaling pathway
On-line přístup:	https://doi.org/10.1186/s12931-023-02656-3
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