Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes

ABSTRACT Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin. In this study, we found that patients with S. aureus respiratory tra...

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Detalhes bibliográficos

Principais autores:	Srikanth Mairpady Shambat, Puran Chen, Rocky M. Barilla, Markus Huemer, Johanna Snäll, Amanda Welin, Taylor S. Cohen, Virginia Takahashi, Samuel B. Berry, Alejandro Gómez-Mejia, Tiziano A. Schweizer, Danen M. Cunoosamy, Sara Cajander, Magda Lourda, Volkan Özenci, Ewerton Marques Maggio, Reto A. Schüpbach, Kristoffer Strålin, Annelies S. Zinkernagel, Anna Norrby-Teglund, Mattias Svensson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-11-01
coleção:	mBio
Assuntos:	Staphylococcus aureus CX3CL1 α-toxin ADAM10 monocytes chemotaxis
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.02689-25
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