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T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges

Summary: T cell-engaging bispecific antibodies (T-BsAbs) have revolutionized immunotherapy for hematologic malignancies, showing promise in lymphoid cancers and myeloma. However, their application in myeloid malignancies like acute myeloid leukemia (AML) faces challenges due to myelotoxicity and lim...

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Hlavní autoři: Sophie Paczesny, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Nai-Kong V. Cheung
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-05-01
Edice:Cell Reports Medicine
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2666379126001898
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