Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

A small, nucleotide-binding domain, the ATP-cone, is found at the N-terminus of most ribonucleotide reductase (RNR) catalytic subunits. By binding adenosine triphosphate (ATP) or deoxyadenosine triphosphate (dATP) it regulates the enzyme activity of all classes of RNR. Functional and structural work...

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Principais autores:	Ornella Bimai, Ipsita Banerjee, Inna Rozman Grinberg, Ping Huang, Lucas Hultgren, Simon Ekström, Daniel Lundin, Britt-Marie Sjöberg, Derek T Logan
Formato:	Artigo
Idioma:	Inglês
Publicado:	eLife Sciences Publications Ltd 2024-07-01
Series:	eLife
Assuntos:	Prevotella copri ribonucleotide reductase glycyl radical allosteric regulation ATP-cone
Acceso en liña:	https://elifesciences.org/articles/89292
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