Partial inhibition of viral replication machinery enhances recombination in herpes simplex viruses

Abstract Background Herpes simplex viruses (HSV-1 and HSV-2) are widespread human pathogens, most commonly causing oral and genital lesions. These DNA viruses use recombination as a major driver of evolution. Intragenomic and intergenomic recombination events can be detected both in vivo and in vitr...

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Principais autores:	Maya Ralph-Altman, Daniel Avhar, Yuval Altman, Itai Cohen, Hadas Azulay, Tal Korner, Sireen Sweed, Enosh Tomer, Oren Kobiler
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-12-01
Series:	Biology Direct
Assuntos:	Herpesviruses Viral recombination Antivirals Polymerase inhibitors Helicase-primase inhibitors
Acceso en liña:	https://doi.org/10.1186/s13062-025-00711-1
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