Extending the Affinity Range of Weak Affinity Chromatography for the Identification of Weak Ligands Targeting Membrane Proteins

The identification of weak-affinity ligands targeting membrane proteins is of great interest in Fragment-Based Drug Design (FBDD). Recently, miniaturized weak affinity chromatography (WAC) has been proposed as a valuable tool to study interactions between small ligands and wild-type membrane protein...

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Autors principals:	Adrien Deloche, François-Xavier Vidal, Lucile Jammas, Renaud Wagner, Vincent Dugas, Claire Demesmay
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-10-01
Col·lecció:	Molecules
Matèries:	membrane proteins affinity chromatography surface functionalization weak-affinity interactions adenosine receptor fragment-based drug discovery
Accés en línia:	https://www.mdpi.com/1420-3049/28/20/7113
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