Interlaboratory assessment of candidate reference materials for lentiviral vector copy number and integration site measurements

While lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, safety concerns remain regarding potential insertional mutagenesis. Regulatory authorities strongly recommend risk assessment and management of vector copy numbers (VCNs), integration profiles, and...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Hua-Jun He, Zhiyong He, Steven P. Lund, Laure Turner, Yongjun Fan, Yu Qiu, David C. Corney, Boro Dropulic, Rimas Orentas, Oxana Slessareva, Priscilla Welch, Katie Dungca, Ellen Stelloo, Gabrielle Dijksteel, Harma Feitsma, Sana Ahmed-Seghir, Rostyslav Makarenko, Engin Altunlu, Daniëlle Steenmans, Jan Spanholtz, Monica Raimo, Shai Senderovich, Barbara S. Paugh, Chieh-Yuan Li, Benjamin Schroeder, Alexandra S. Whale, Dilek Yener, Carole A. Foy, Shareef Nahas, Feng Tu, Michael Sheldon, Yan Ding, Jennifer Kandell, Uma Lakshmipathy, Jennifer H. McDaniel, Justin M. Zook, Sierra Miller, Samantha Maragh, Simona Patange, Mahir Mohiuddin, Alessandro Tona, Kenneth D. Cole, Sheng Lin-Gibson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-06-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	lentiviral vector, LV vector copy number, VCN integration site analysis next generation sequencing NGS reference material
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050125000671
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!