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Cancer risk in patients with pulmonary fibrosis and a rare telomere related gene variant

Abstract Background Rare telomere related gene (TRG) variants are the cause of telomere biology disorders (TBD), a broad spectrum of age-related diseases, such as pulmonary fibrosis (PF) a disease manifesting at older age. TBD patients are at increased risk of certain types of squamous cell carcinom...

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Principais autores: Joanne J. van der Vis, Martijn T. K. Maus, Charlotte I. de Bie, Jasper J. van der Smagt, Laura G. M. Daenen, Matthijs F.M. van Oosterhout, Jan C. Grutters, Coline H. M. van Moorsel
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Respiratory Research
Assuntos:
Pulmonary fibrosis
Telomere biology disorder
Genetic counselling
Cancer
Myelodysplastic syndrome
Acesso em linha:https://doi.org/10.1186/s12931-025-03469-2
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