The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player?

The complement system is a key component of the innate immune system. In antiacetylcholine receptor (AChR) antibody-positive (Ab+) generalized myasthenia gravis (MG), complement activation has long been considered a principal driver of pathology. Understanding the role of complement in AChR-Ab+ gene...

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Autori principali:	Iliana Michailidou, Anastasia Patsiarika, Evangelia Kesidou, Marina Kleopatra Boziki, Dimitrios Parisis, Christos Bakirtzis, Elisabeth Chroni, Nikolaos Grigoriadis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-04-01
Serie:	Frontiers in Immunology
Soggetti:	myasthenia gravis complement system anti-acetylcholine receptor antibodies membrane attack complex therapy
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526317/full
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