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Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies

Abstract VEGFR2 and FAK signaling pathways are interconnected and have synergistic effects on tumor angiogenesis, growth, and metastasis. Thus, instead of the conventional targeting of each of these proteins individually with a specific inhibitor, the present work aimed to discover novel dual inhibi...

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Autori principali: Marwa A. Fouad, Alaa A. Osman, Noha M. Abdelhamid, Mai W. Rashad, Ashrakat Y. Nabawy, Ahmed M. El Kerdawy
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-02-01
Serie:BMC Chemistry
Soggetti:
Pharmacophore modelling
Virtual screening
Molecular docking
Cancer
FAK
VEGFR2
Accesso online:https://doi.org/10.1186/s13065-024-01130-5
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