Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain

Background A growing body of evidence suggests that ATP-gated P2X3 receptors (P2X3Rs) are implicated in chronic pain. We address the possibility that stable, synthetic analogs of diadenosine tetraphosphate (Ap 4 A) might induce antinociceptive effects by inhibiting P2X3Rs in peripheral sensory neuro...

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Autori principali:	Viacheslav Viatchenko-Karpinski PhD, Natalia Novosolova PhD, Yevheniia Ishchenko MSc, M Ameruddin Azhar PhD, Michael Wright PhD, Vera Tsintsadze PhD, Ahmed Kamal PhD, Nail Burnashev PhD, DrSc, Andrew D Miller PhD, Nana Voitenko PhD, DrSc, Rashid Giniatullin MD, PhD, Natalia Lozovaya PhD, DrSc
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SAGE Publishing 2016-03-01
Serie:	Molecular Pain
Accesso online:	https://doi.org/10.1177/1744806916637704
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