Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein. In this study, we have identified protein aggre...

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Autors principals:	Katherine J. Robinson, Madelaine C. Tym, Alison Hogan, Maxinne Watchon, Kristy C. Yuan, Stuart K. Plenderleith, Emily K. Don, Angela S. Laird
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2021-10-01
Col·lecció:	Disease Models & Mechanisms
Matèries:	spinocerebellar ataxia 3 machado–joseph disease hereditary spinocerebellar ataxias neurodegenerative disease flow cytometry proteinopathy insoluble protein species protein aggregates
Accés en línia:	http://dmm.biologists.org/content/14/10/dmm049023
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