Cryopreserved exosomes derived from hypoxic Wharton’s jelly mesenchymal stromal cells enhance fibroblast proliferation, upregulate COL1A2 expression, and mitigate senescence

Mesenchymal stromal cells (MSCs) and their exosomes support regeneration by modulating inflammation and promoting tissue repair. Hypoxic preconditioning enhances the regenerative potential of MSCs by enriching their secretome with trophic and immunomodulatory factors. This study evaluated the biolog...

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Principais autores:	Carolina Quintero-Gil, Wendy Jaraba-Alvarez, Juan P Franco-Salazar, Yurany Blanquiceth, Ferley A Bedoya-Guzmán, Sofía Ortiz-Tamayo, Natalia Quiroz-Correa, Vanesa Sanchez-Giraldo, Karolynn Halpert, Héctor Ortega-Arellano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
coleção:	Frontiers in Medicine
Assuntos:	exosomes mesenchymal stromal cells hypoxic preconditioning fibroblast proliferation COL1A2 expression cellular senescence
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1692585/full
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