Discovery of second generation heat shock protein 110 (HSP110) inhibitors for potential treatment of colorectal cancer

Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported HSP110 modulator (hit 1). Among the novel compound...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-04-01
Schriftenreihe:	European Journal of Medicinal Chemistry Reports
Schlagworte:	HSP110 Inhibitor Colorectal cancer STAT3
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2772417423000031
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!