Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

The spread of antimicrobial resistance and vaccine escape in the human pathogen Streptococcus pneumoniae can be largely attributed to competence-induced transformation. Here, we studied this process at the single-cell level. We show that within isogenic populations, all cells become naturally compet...

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Prif Awduron:	Jun Kurushima, Nathalie Campo, Renske van Raaphorst, Guillaume Cerckel, Patrice Polard, Jan-Willem Veening
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	eLife Sciences Publications Ltd 2020-09-01
Cyfres:	eLife
Pynciau:	Streptococcus pneumoniae transformation competence development recombination single cell analysis horizontal gene transfer
Mynediad Ar-lein:	https://elifesciences.org/articles/58771
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