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Dose-response immunomodulatory effects of Mesenchymal stem cell-derived culture-conditioned media in acute Graft-versus-Host Disease

Background: Mesenchymal stem cell-based therapy faces challenges that have driven interest in MSCs-derived culture-conditioned media (CCM) as a cell-free alternative. Our study aims to optimize the dose and collection timing of CCM to enhance its therapeutic efficacy in aGVHD, while also standardizi...

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Автори: Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Sandeep Rai, Ritu Gupta, Vatsla Dadhwal, Sameer Bakhshi, Deepam Pushpam, Mukul Aggarwal, Aditya Kumar Gupta, Ranjit Kumar Sahoo
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2025-12-01
Серія:Regenerative Therapy
Предмети:
Mesenchymal stem cells
Culture-conditioned media
Bone marrow
Wharton's Jelly
Immunomodulation
Acute Graft-versus-Host-Disease
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2352320425001981
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