Mouse and human embryonic genome activation initiate at the one-cell stage

At the moment of their union, fertilizing gametes (sperm and oocyte) are transcriptionally silent: gene expression has to be initiated within the resulting embryo, a process termed embryonic genome activation, EGA. Until recently, EGA was believed to occur at the two-cell stage (mouse) or four-to-ei...

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Bibliografske podrobnosti

Principais autores:	Maki Asami, Anthony C. F. Perry
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-07-01
Serija:	Frontiers in Cell and Developmental Biology
Teme:	transcription fertilization one-cell embryo embryonic genome activation (EGA) immediate EGA zygotic genome activation (ZGA)
Online dostop:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1594995/full
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