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Screening of the Pandemic Response Box Reveals an Association between Antifungal Effects of MMV1593537 and the Cell Wall of Cryptococcus neoformans, Cryptococcus deuterogattii, and Candida auris

ABSTRACT There is an urgent unmet need for novel antifungals. In this study, we searched for novel antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse compounds in various phases of drug discovery. We identified five molecules which could control the growth o...

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Principais autores: Haroldo C. de Oliveira, Rafael F. Castelli, Flavia C. G. Reis, Kirandeep Samby, Joshua D. Nosanchuk, Lysangela R. Alves, Marcio L. Rodrigues
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2022-06-01
coleção:Microbiology Spectrum
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Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.00601-22
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