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Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples

Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as a therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating NAMPT to perpetuate inflammation are yet to be investigated. We continuously monitored and...

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Autori principali: Ming Lei, Meng-Qing Tao, Yi-Jin Wu, Liang Xu, Zhe Yang, Yan Li, Opeyemi Joshua Olatunji, Xiao-Wan Wang, Jian Zuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-01-01
Serie:Frontiers in Immunology
Soggetti:
triosephosphate isomerase 1 (TPI1)
rheumatoid arthritis (RA)
collagen-induced arthritis (CIA)
metabolism reprogramming
glycolysis
monocytes
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2021.795626/full
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