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Modeling Chronic BaP Exposure in Bronchial Epithelial Cells Reveals Multi-Scale Drivers of Early Preneoplastic Reprogramming

Chronic exposure to benzo[a]pyrene (BaP), a Group 1 IARC carcinogen, is a major driver of lung carcinogenesis; however, how sustained subcytotoxic exposure reprograms bronchial epithelium toward preneoplastic states remains poorly defined. Here, we subjected BEAS-2B human bronchial epithelial cells...

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I tiakina i:
Ngā kaituhi matua: Cristian Andrade-Madrigal, Cecilia Rojas-Fuentes, Javier Díaz-Mijares, Gloria M. Calaf, Pablo M. Santoro, Alejandro H. Corvalán, Francisca J. Medina, Cristian G. Torres, Paula Romero-Vicencio, Julio C. Tapia, Mónica L. Acevedo, Ricardo Soto-Rifo, Enrique Boccardo, Francisco Aguayo
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2026-03-01
Rangatū:Cells
Ngā marau:
lung carcinogenesis
benzo[a]pyrene
BPDE
chronic exposure
DDR
ATM
Urunga tuihono:https://www.mdpi.com/2073-4409/15/6/566
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