Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward

Despite the prevalence of opioid misuse, opioids remain the frontline treatment regimen for severe pain. However, opioid safety is hampered by side-effects such as analgesic tolerance, reduced analgesia to neuropathic pain, physical dependence, or reward. These side effects promote development of op...

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Autors principals:	Mackenzie C. Gamble, Benjamin R. Williams, Navsharan Singh, Luca Posa, Zachary Freyberg, Ryan W. Logan, Stephanie Puig
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-12-01
Col·lecció:	Frontiers in Systems Neuroscience
Matèries:	mu-opioid receptor opioid signaling pain tolerance neuropathic pain physical dependence
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnsys.2022.1059089/full
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