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Erythrocyte Efferocytosis by the Arterial Wall Promotes Oxidation in Early-Stage Atheroma in Humans

BackgroundSince red blood cells (RBCs) are the predominant cellular blood component interacting with the arterial wall, we explored the role of RBCs efferocytosis by vascular smooth muscle cells (vSMCs) in the initiation of human atheroma.Methods and resultsThe comparison of human healthy aortas wit...

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Principais autores: Sandrine Delbosc, Richard Graham Bayles, Jamila Laschet, Veronique Ollivier, Benoit Ho-Tin-Noé, Ziad Touat, Catherine Deschildre, Marion Morvan, Liliane Louedec, Laurent Gouya, Kevin Guedj, Antonino Nicoletti, Jean-Baptiste Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-08-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
smooth muscle cells
oxidative stress
iron
fatty streaks
hemoglobin
translational studies
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fcvm.2017.00043/full
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