利多卡因对脂多糖诱导的HK-2细胞炎症反应及TLR4/NF-κB通路的影响
目的 探讨利多卡因对脂多糖(lipopolysaccharide, LPS)诱导的脓毒症肾损伤的保护作用及机制。方法 将肾小管上皮细胞(HK-2)分为空白对照组、LPS组和LPS+利多卡因组。细胞增殖与毒性试剂(cell counting kit-8,CCK-8)法检测细胞增殖活性,采用酶联免疫吸附试验(ELISA)检测各组HK-2细胞炎症因子高迁移率族蛋白B1(high mobility group protein B1,HMGB1)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)表达水平,比较各组间上述...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Chinês |
| Udgivet: |
Editorial Office of Chinese Journal of Laboratory Diagnosis
2024-01-01
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| Serier: | Zhongguo shiyan zhenduanxue |
| Fag: | |
| Online adgang: | http://ZSZD.publish.founderss.cn/thesisDetails?columnId=88419197&Fpath=home&index=0 |
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