Avena sativa-derived avenanthramides suppress 12-lipoxygenase activity and downstream arachidonic acid metabolites in letrozole-induced PCOS rats

Abstract Polycystic ovary syndrome (PCOS) implicates hormonal imbalance, ovulation disorders, metabolic disturbances, and chronic low-grade inflammation. In this study, we investigated the inflammation driven by 12-lipoxygenase (12-LOX)-mediated conversion of arachidonic acid to pro-inflammatory 12-...

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Hauptverfasser:	Yara Walid, Raghda A. Elsabbagh, Heba Handoussa, Sahar M. Abdel-Maksoud
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-06-01
Schriftenreihe:	Scientific Reports
Schlagworte:	12-lipoxygenase (12-LOX) 12-hydroxyeicosatetraenoic acid (12-HETE) Avenanthramide Letrozole Oats extract Polycystic ovary syndrome (PCOS)
Online-Zugang:	https://doi.org/10.1038/s41598-026-56474-w
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