Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Abstract Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable candidate. Methods A randomized, dou...

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Autori principali:	Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2020-01-01
Serie:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Soggetti:	allopregnanolone Alzheimer’s disease maximally tolerated dose neurogenesis pharmacokinetics phase 1 clinical trial
Accesso online:	https://doi.org/10.1002/trc2.12107
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