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Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

Abstract Background Apolipoprotein E (ApoE) is the major carrier protein that mediates the transport and delivery of cholesterol and other lipids in the brain. Three isoforms of ApoE (ApoE2, ApoE3, ApoE4) exist in humans, and their relative expression levels impact HIV-1 infection, HIV-1/AIDS diseas...

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Autori principali: Nabab Khan, Gaurav Datta, Jonathan D. Geiger, Xuesong Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2018-03-01
Serie:Journal of Neuroinflammation
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Accesso online:http://link.springer.com/article/10.1186/s12974-018-1129-1
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